Melvin Smiley, a successful young hitman, is living a normal all-day life for his jewish fiancé Pam, but kills for money in Paris' organization. In addition, he has a relationship with a beauty from the neighbourhood and gets bothered by a pimply video store guy, because he did not return "King Kong Lives" for two weeks. He and his three teammates Cisco, Crunch and Vince one day decide to kidnap the daughter of super-rich businessman Jiro Nishi - off the record. What they do not know, is that Jiro just went completely bankrupt due to a successless movie production, and, even worse, that his daughter Keiko is the god-daughter of Paris, the boss of the kidnappers. He and his men are now searching for the kidnappers in order to grind them up properly. Meanwhile, handcuffed Keiko falls in love with killer Melvin while both preparing a kosher meal in order to satisfy Pam's visiting parents, who are out of the house with Pam - with a body in the trunk.

In the Plum Island, off the coast of Delaware, the long feud between the families of the patriarchs Captain Patrick O'Flynn (Kenneth Welsh) that intends to eliminate the zombies and Seamus Muldoon (Richard Fitzpatrick) that intends to keep his undead relatives waiting for a cure culminates with O'Flynn expelled from Plum. Meanwhile in the continent Sarge "Nicotine" Crocket (Alan Van Sprang), Chuck (Joris Jarsky), Cisco (Stefano DiMatteo) and Tomboy (Athena Karkanis) are plundering and seeking a safe place to stay. When they rescue the young Boy (Devon Bostick) from group of sadistic hunters, Boy decides to join the group and suggests them to head to Plum Island since he had heard a O'Flynn's broadcast inviting people to move to the island. When Sarge and his team arrive in the island, they are attacked by Muldoon's men and they see that the place is crowded of undead. Sarge's friend Chuck is killed and they decide to fight against Muldoon.